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GADD45A (Growth arrest and DNA damage-inducible protein GADD45 alpha) is a gene. The public catalogues list it as a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer.
In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity. Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.
In plain words · GADD45A (Growth arrest and DNA damage-inducible protein GADD45 alpha) is a gene. The public catalogues list it as a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer.
GADD45A (Growth arrest and DNA damage-inducible protein GADD45 alpha) is a gene. The public catalogues list it as a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer.
In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity.
No product in this corpus aims at GADD45A yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA GADD45A: RNA low tissue specificity; blood lineage group enriched (granulocytes 49 nTPM, T-cells 19 nTPM); no normal tissue stained high. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Ovarian cancer); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas GADD45A tissue; Open Targets ENSG00000116717 associations
First described 1991. Earliest sequence paper UniProt cites for the protein: Papathanasiou M.A. et al, Mol. Cell. Biol, 1991, "Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase C". Source.
Sources: HGNC HGNC:4095 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P24522 (protein name, function text, keywords and locations (REST API)); CIViC gene GADD45A (1 evidence items, 0 assertions, 1 variants; diseases: Ovarian Cancer (GraphQL API, CC0))
In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity. Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. Location: Nucleus (UniProt). Locus 1p31.3 (HGNC).
RNA: low tissue specificity, detected in all normal tissues. Blood: group enriched (granulocytes 49 nTPM, T-cells 19 nTPM).
No normal tissue stained high.
No cancer sample stained medium or high.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"GADD45A" OR ABSTRACT:"GADD45A" OR TITLE:"growth arrest and DNA damage inducible alpha" OR ABSTRACT:"growth arrest and DNA damage inducible alpha" OR TITLE:"Growth arrest and DNA damage-inducible protein GADD45 alpha" OR ABSTRACT:"Growth arrest and DNA damage-inducible protein GADD45 alpha" OR TITLE:"GADD45" OR ABSTRACT:"GADD45" OR TITLE:"DDIT1" OR ABSTRACT:"DDIT1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about GADD45A, not a curated reading list.