{"entity":{"id":"gadd45a","kind":"target","name":"GADD45A","aka":["growth arrest and DNA damage inducible alpha","Growth arrest and DNA damage-inducible protein GADD45 alpha","GADD45","DDIT1"],"tldr":"GADD45A (Growth arrest and DNA damage-inducible protein GADD45 alpha) is a gene. The public catalogues list it as a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer.","summary":"In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity. Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:4095","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4095"},{"label":"UniProt P24522","url":"https://www.uniprot.org/uniprotkb/P24522/entry"},{"label":"NCBI Gene 1647","url":"https://www.ncbi.nlm.nih.gov/gene/1647"},{"label":"Ensembl ENSG00000116717","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000116717"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["ovarian"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants; UniProt keyword \"DNA damage\". Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"GADD45A","role":["biomarker","dna-repair"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:4095","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4095","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P24522","url":"https://www.uniprot.org/uniprotkb/P24522/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene GADD45A","url":"https://civicdb.org/features/1411","note":"1 evidence items, 0 assertions, 1 variants; diseases: Ovarian Cancer (GraphQL API, CC0)"}],"specificity":"broadly-expressed","distribution":"one-type","specificityNote":"Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA GADD45A: RNA low tissue specificity; blood lineage group enriched (granulocytes 49 nTPM, T-cells 19 nTPM); no normal tissue stained high. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Ovarian cancer); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"Human Protein Atlas GADD45A tissue","url":"https://www.proteinatlas.org/ENSG00000116717-GADD45A/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000116717 associations","url":"https://platform.opentargets.org/target/ENSG00000116717/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:4095","ensembl":"ENSG00000116717","uniprot":"P24522","entrez":"1647","firstDescribed":1991,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Papathanasiou M.A. et al, Mol. Cell. Biol, 1991, \"Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase C\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/1990262/","biology":"In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity. Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. Location: Nucleus (UniProt). Locus 1p31.3 (HGNC).","whereFound":["Ovarian cancer: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/gadd45a/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"}]}}