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GABRG3 (Gamma-aminobutyric acid receptor subunit gamma-3) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Gamma subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s). When activated by GABA, GABAARs selectively allow the flow of chloride across the cell membrane down their electrochemical gradient.
Open Targets scores its association with cancer at 0.50 (direct and indirect evidence; datatypes literature 0.16, genetic association 0.51, clinical 0.66).
In plain words · GABRG3 (Gamma-aminobutyric acid receptor subunit gamma-3) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
GABRG3 (Gamma-aminobutyric acid receptor subunit gamma-3) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Gamma subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain.
No product in this corpus aims at GABRG3 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA GABRG3: RNA tissue enhanced (prostate 6 nTPM, retina 25 nTPM, testis 9 nTPM); no normal tissue stained high. Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas GABRG3 tissue; Open Targets ENSG00000182256 associations
First described 1995. Earliest sequence paper UniProt cites for the protein: Hadingham K.L. et al, Eur. J. Pharmacol, 1995, "Expression and pharmacology of human GABAA receptors containing gamma 3 subunits". Source.
Sources: HGNC HGNC:4088 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q99928 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000182256 (association with cancer (MONDO_0004992) 0.50; (GraphQL API, CC0))
Gamma subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s). When activated by GABA, GABAARs selectively allow the flow of chloride across the cell membrane down their electrochemical gradient. Location: Postsynaptic cell membrane; Cell membrane (UniProt). Locus 15q12 (HGNC).
RNA: tissue enhanced (prostate 6 nTPM, retina 25 nTPM, testis 9 nTPM), detected in some normal tissues.
No normal tissue stained high; medium in Cerebral cortex, Epididymis.
RNA cancer enhanced: Prostate Adenocarcinoma 10 pTPM.
No cancer stained high; medium in carcinoid, endometrial cancer, glioma, prostate cancer.
HPA GABRG3 tissue · HPA GABRG3 pathology · HPA protein class: FDA approved drug targets
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"GABRG3" OR ABSTRACT:"GABRG3" OR TITLE:"gamma-aminobutyric acid type A receptor subunit gamma3" OR ABSTRACT:"gamma-aminobutyric acid type A receptor subunit gamma3" OR TITLE:"Gamma-aminobutyric acid receptor subunit gamma-3" OR ABSTRACT:"Gamma-aminobutyric acid receptor subunit gamma-3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about GABRG3, not a curated reading list.