{"entity":{"id":"gabrg3","kind":"target","name":"GABRG3","aka":["gamma-aminobutyric acid type A receptor subunit gamma3","Gamma-aminobutyric acid receptor subunit gamma-3"],"tldr":"GABRG3 (Gamma-aminobutyric acid receptor subunit gamma-3) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.","summary":"Gamma subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s). When activated by GABA, GABAARs selectively allow the flow of chloride across the cell membrane down their electrochemical gradient.\n\nOpen Targets scores its association with cancer at 0.50 (direct and indirect evidence; datatypes literature 0.16, genetic association 0.51, clinical 0.66).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:4088","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4088"},{"label":"UniProt Q99928","url":"https://www.uniprot.org/uniprotkb/Q99928/entry"},{"label":"NCBI Gene 2567","url":"https://www.ncbi.nlm.nih.gov/gene/2567"},{"label":"Ensembl ENSG00000182256","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000182256"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.66. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"GABRG3","role":["drug-target"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:4088","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4088","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q99928","url":"https://www.uniprot.org/uniprotkb/Q99928/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000182256","url":"https://platform.opentargets.org/target/ENSG00000182256/associations","note":"association with cancer (MONDO_0004992) 0.50;  (GraphQL API, CC0)"}],"distribution":"not-established","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA GABRG3: RNA tissue enhanced (prostate 6 nTPM, retina 25 nTPM, testis 9 nTPM); no normal tissue stained high. Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas GABRG3 tissue","url":"https://www.proteinatlas.org/ENSG00000182256-GABRG3/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000182256 associations","url":"https://platform.opentargets.org/target/ENSG00000182256/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:4088","ensembl":"ENSG00000182256","uniprot":"Q99928","entrez":"2567","firstDescribed":1995,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Hadingham K.L. et al, Eur. J. Pharmacol, 1995, \"Expression and pharmacology of human GABAA receptors containing gamma 3 subunits\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/8719414/","biology":"Gamma subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s). When activated by GABA, GABAARs selectively allow the flow of chloride across the cell membrane down their electrochemical gradient. Location: Postsynaptic cell membrane; Cell membrane (UniProt). Locus 15q12 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/gabrg3/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}