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GAB1 (GRB2-associated-binding protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Adapter protein that plays a role in intracellular signalling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signalling. Probably involved in signalling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR).
Open Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.93, affected pathway 0.82, animal model 0.50, genetic association 0.14).
In plain words · GAB1 (GRB2-associated-binding protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
GAB1 (GRB2-associated-binding protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Adapter protein that plays a role in intracellular signalling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signalling.
No product in this corpus aims at GAB1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1996. Earliest sequence paper UniProt cites for the protein: Holgado-Madruga et al, Nature, 1996, "A Grb2-associated docking protein in EGF- and insulin-receptor signalling". Source.
Sources: HGNC HGNC:4066 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q13480 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000109458 (association with cancer (MONDO_0004992) 0.65; (GraphQL API, CC0))
Adapter protein that plays a role in intracellular signalling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signalling. Probably involved in signalling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signalling pathway. Locus 4q31.21 (HGNC).
Query for this target: (TITLE:"GAB1" OR ABSTRACT:"GAB1" OR TITLE:"GRB2 associated binding protein 1" OR ABSTRACT:"GRB2 associated binding protein 1" OR TITLE:"GRB2-associated-binding protein 1" OR ABSTRACT:"GRB2-associated-binding protein 1" OR TITLE:"DFNB26" OR ABSTRACT:"DFNB26") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about GAB1, not a curated reading list.