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FRS2 (Fibroblast growth factor receptor substrate 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Adapter protein that links activated FGR and NGF receptors to downstream signalling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signalling via SHC1 by competing for a common binding site on NTRK1.
Open Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.68, affected pathway 0.90, genetic association 0.00).
In plain words · FRS2 (Fibroblast growth factor receptor substrate 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
FRS2 (Fibroblast growth factor receptor substrate 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Adapter protein that links activated FGR and NGF receptors to downstream signalling pathways.
No product in this corpus aims at FRS2 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1998. Earliest sequence paper UniProt cites for the protein: Xu et al, J. Biol. Chem, 1998, "Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins". Source.
Sources: HGNC HGNC:16971 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8WU20 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000166225 (association with cancer (MONDO_0004992) 0.65; (GraphQL API, CC0))
Adapter protein that links activated FGR and NGF receptors to downstream signalling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signalling via SHC1 by competing for a common binding site on NTRK1. Location: Endomembrane system (UniProt). Locus 12q15 (HGNC).
Query for this target: (TITLE:"FRS2" OR ABSTRACT:"FRS2" OR TITLE:"fibroblast growth factor receptor substrate 2" OR ABSTRACT:"fibroblast growth factor receptor substrate 2" OR TITLE:"Fibroblast growth factor receptor substrate 2" OR ABSTRACT:"Fibroblast growth factor receptor substrate 2" OR TITLE:"SNT-1" OR ABSTRACT:"SNT-1" OR TITLE:"FRS2alpha" OR ABSTRACT:"FRS2alpha" OR TITLE:"SNT1" OR ABSTRACT:"SNT1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FRS2, not a curated reading list.