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FOXR2 (Forkhead box protein R2) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
UniProt has no function text for Q6PJQ5; HGNC names it "forkhead box R2".
CIViC holds 3 clinical evidence items and 2 assertions across 1 variant.
In plain words · FOXR2 (Forkhead box protein R2) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
FOXR2 (Forkhead box protein R2) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
UniProt has no function text for Q6PJQ5; HGNC names it "forkhead box R2". Location: Nucleus (UniProt).
No product in this corpus aims at FOXR2 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role biomarker; HPA finds the RNA tissue enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA FOXR2: RNA tissue enriched (testis 1 nTPM); no normal tissue stained high; highest cancer staining thyroid cancer (2 of 4 high). Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas FOXR2 tissue; Open Targets ENSG00000189299 associations
First described 2004. Earliest sequence paper UniProt cites for the protein: Genome Res, 2004, "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Source.
Sources: HGNC HGNC:30469 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q6PJQ5 (protein name, function text, keywords and locations (REST API)); CIViC gene FOXR2 (3 evidence items, 2 assertions, 1 variants; diseases: CNS Neuroblastoma With FOXR2 Activation (GraphQL API, CC0))
UniProt has no function text for Q6PJQ5; HGNC names it "forkhead box R2". Location: Nucleus (UniProt). Locus Xp11.21 (HGNC).
RNA: tissue enriched (testis 1 nTPM), detected in single normal tissue.
No normal tissue stained high.
Medium only: glioma, head and neck cancer, renal cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"FOXR2" OR ABSTRACT:"FOXR2" OR TITLE:"forkhead box R2" OR ABSTRACT:"forkhead box R2" OR TITLE:"Forkhead box protein R2" OR ABSTRACT:"Forkhead box protein R2" OR TITLE:"MGC21658" OR ABSTRACT:"MGC21658" OR TITLE:"FOXN6" OR ABSTRACT:"FOXN6") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FOXR2, not a curated reading list.