{"entity":{"id":"foxr2","kind":"target","name":"FOXR2","aka":["forkhead box R2","Forkhead box protein R2","MGC21658","FOXN6"],"tldr":"FOXR2 (Forkhead box protein R2) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.","summary":"UniProt has no function text for Q6PJQ5; HGNC names it \"forkhead box R2\".\n\nCIViC holds 3 clinical evidence items and 2 assertions across 1 variant.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:30469","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30469"},{"label":"UniProt Q6PJQ5","url":"https://www.uniprot.org/uniprotkb/Q6PJQ5/entry"},{"label":"NCBI Gene 139628","url":"https://www.ncbi.nlm.nih.gov/gene/139628"},{"label":"Ensembl ENSG00000189299","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000189299"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 3 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate.","Diseases the sources name that have no OnCo cancer page yet, so they are not linked: CNS Neuroblastoma With FOXR2 Activation."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"FOXR2","role":["biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:30469","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30469","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q6PJQ5","url":"https://www.uniprot.org/uniprotkb/Q6PJQ5/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene FOXR2","url":"https://civicdb.org/features/18440","note":"3 evidence items, 2 assertions, 1 variants; diseases: CNS Neuroblastoma With FOXR2 Activation (GraphQL API, CC0)"}],"distribution":"not-established","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role biomarker; HPA finds the RNA tissue enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA FOXR2: RNA tissue enriched (testis 1 nTPM); no normal tissue stained high; highest cancer staining thyroid cancer (2 of 4 high). Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas FOXR2 tissue","url":"https://www.proteinatlas.org/ENSG00000189299-FOXR2/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000189299 associations","url":"https://platform.opentargets.org/target/ENSG00000189299/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:30469","ensembl":"ENSG00000189299","uniprot":"Q6PJQ5","entrez":"139628","firstDescribed":2004,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Genome Res, 2004, \"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/15489334/","biology":"UniProt has no function text for Q6PJQ5; HGNC names it \"forkhead box R2\". Location: Nucleus (UniProt). Locus Xp11.21 (HGNC).","whereFound":[],"targetClass":"transcription","prevalence":[]},"route":"/targets/foxr2/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}]}}