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FOS (Fos proto-oncogene, AP-1 transcription factor subunit) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.
Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signalling.
CIViC holds 3 clinical evidence items and 1 assertion across 2 variants, naming Irbesartan.
In plain words · FOS (Fos proto-oncogene, AP-1 transcription factor subunit) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.
FOS (Fos proto-oncogene, AP-1 transcription factor subunit) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.
Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites.
No product in this corpus aims at FOS yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA FOS: RNA low tissue specificity; blood lineage lineage enriched (granulocytes 507 nTPM); high antibody staining in 11 normal tissues; highest cancer staining head and neck cancer (2 of 3 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Colorectal cancer); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas FOS tissue; Open Targets ENSG00000170345 associations
First described 1983. Earliest sequence paper UniProt cites for the protein: van Straaten et al, Proc. Natl. Acad. Sci. U.S.A, 1983, "Complete nucleotide sequence of a human c-onc gene: deduced amino acid sequence of the human c-fos protein". Source.
Sources: HGNC HGNC:3796 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P01100 (protein name, function text, keywords and locations (REST API)); CIViC gene FOS (3 evidence items, 1 assertions, 2 variants; diseases: Osteoblastoma, Colon Adenocarcinoma (GraphQL API, CC0))
Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signalling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. Location: Nucleus; Endoplasmic reticulum; Cytoplasm, cytosol (UniProt). Locus 14q24.3 (HGNC).
RNA: low tissue specificity, detected in all normal tissues. Blood: lineage enriched (granulocytes 507 nTPM).
Medium: Appendix, Bone marrow, Cerebellum, Colon, Duodenum, Endometrium, Esophagus, Heart muscle.
Medium only: breast cancer, carcinoid, melanoma, ovarian cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"FOS" OR ABSTRACT:"FOS" OR TITLE:"Fos proto-oncogene, AP-1 transcription factor subunit" OR ABSTRACT:"Fos proto-oncogene, AP-1 transcription factor subunit" OR TITLE:"c-fos" OR ABSTRACT:"c-fos" OR TITLE:"AP-1" OR ABSTRACT:"AP-1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FOS, not a curated reading list.