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FNTB (Protein farnesyltransferase subunit beta) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer.
Essential subunit of the farnesyltransferase complex. Catalyses the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Lonafarnib.
In plain words · FNTB (Protein farnesyltransferase subunit beta) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer.
FNTB (Protein farnesyltransferase subunit beta) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer.
Essential subunit of the farnesyltransferase complex.
No product in this corpus aims at FNTB yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
Broadly expressed or essential: HPA lists FNTB among essential proteins; a medicine acting on the wild-type protein would expose normal tissue too. HPA FNTB: RNA tissue enriched (brain 136 nTPM); no normal tissue stained high. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Ovarian cancer); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas FNTB tissue; Open Targets ENSG00000257365 associations
First described 1993. Earliest sequence paper UniProt cites for the protein: Omer C.A. et al, Biochemistry, 1993, "Characterization of recombinant human farnesyl-protein transferase: cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases". Source.
Sources: HGNC HGNC:3785 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P49356 (protein name, function text, keywords and locations (REST API)); CIViC gene FNTB (1 evidence items, 0 assertions, 1 variants; diseases: Ovarian Cancer (GraphQL API, CC0))
Essential subunit of the farnesyltransferase complex. Catalyses the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Locus 14q23.3 (HGNC).
RNA: tissue enriched (brain 136 nTPM), detected in all normal tissues.
No normal tissue stained high.
No cancer sample stained medium or high.
HPA FNTB tissue · HPA FNTB pathology · HPA protein class: Essential proteins, FDA approved drug targets
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"FNTB" OR ABSTRACT:"FNTB" OR TITLE:"farnesyltransferase, CAAX box, subunit beta" OR ABSTRACT:"farnesyltransferase, CAAX box, subunit beta" OR TITLE:"Protein farnesyltransferase subunit beta" OR ABSTRACT:"Protein farnesyltransferase subunit beta") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FNTB, not a curated reading list.