{"entity":{"id":"fntb","kind":"target","name":"FNTB","aka":["farnesyltransferase, CAAX box, subunit beta","Protein farnesyltransferase subunit beta"],"tldr":"FNTB (Protein farnesyltransferase subunit beta) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer.","summary":"Essential subunit of the farnesyltransferase complex. Catalyses the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Lonafarnib.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:3785","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3785"},{"label":"UniProt P49356","url":"https://www.uniprot.org/uniprotkb/P49356/entry"},{"label":"NCBI Gene 2342","url":"https://www.ncbi.nlm.nih.gov/gene/2342"},{"label":"Ensembl ENSG00000257365","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000257365"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["ovarian"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"FNTB","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:3785","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3785","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P49356","url":"https://www.uniprot.org/uniprotkb/P49356/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene FNTB","url":"https://civicdb.org/features/1950","note":"1 evidence items, 0 assertions, 1 variants; diseases: Ovarian Cancer (GraphQL API, CC0)"}],"specificity":"broadly-expressed","distribution":"one-type","specificityNote":"Broadly expressed or essential: HPA lists FNTB among essential proteins; a medicine acting on the wild-type protein would expose normal tissue too. HPA FNTB: RNA tissue enriched (brain 136 nTPM); no normal tissue stained high. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Ovarian cancer); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"Human Protein Atlas FNTB tissue","url":"https://www.proteinatlas.org/ENSG00000257365-FNTB/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000257365 associations","url":"https://platform.opentargets.org/target/ENSG00000257365/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:3785","ensembl":"ENSG00000257365","uniprot":"P49356","entrez":"2342","firstDescribed":1993,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Omer C.A. et al, Biochemistry, 1993, \"Characterization of recombinant human farnesyl-protein transferase: cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/8494894/","biology":"Essential subunit of the farnesyltransferase complex. Catalyses the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Locus 14q23.3 (HGNC).","whereFound":["Ovarian cancer: CIViC evidence names this disease"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/fntb/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"}]}}