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FGF1 (Fibroblast growth factor 1) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins.
Open Targets scores its association with cancer at 0.71 (direct and indirect evidence; datatypes literature 0.95, affected pathway 0.99, genetic association 0.04, clinical 0.65).
In plain words · FGF1 (Fibroblast growth factor 1) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
FGF1 (Fibroblast growth factor 1) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as a potent mitogen in vitro.
No product in this corpus aims at FGF1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA tissue enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA FGF1: RNA tissue enriched (brain 282 nTPM); high antibody staining in 1 normal tissue. Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 1 specific cancer type at or above 0.5 (female reproductive endometrioid cancer). (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas FGF1 tissue; Open Targets ENSG00000113578 associations
First described 1986. Earliest sequence paper UniProt cites for the protein: Jaye et al, Science, 1986, "Human endothelial cell growth factor: cloning, nucleotide sequence, and chromosome localization". Source.
Sources: HGNC HGNC:3665 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P05230 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000113578 (association with cancer (MONDO_0004992) 0.71; (GraphQL API, CC0))
Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerisation and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signalling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signalling. Location: Secreted; Cytoplasm; Cytoplasm, cell cortex; Cytoplasm, cytosol (UniProt). Locus 5q31.3 (HGNC).
RNA: tissue enriched (brain 282 nTPM), detected in many normal tissues.
RNA cancer enriched: Glioblastoma Multiforme 77 pTPM.
No cancer stained high; medium in glioma.
HPA FGF1 tissue · HPA FGF1 pathology · HPA protein class: FDA approved drug targets
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"FGF1" OR ABSTRACT:"FGF1" OR TITLE:"fibroblast growth factor 1" OR ABSTRACT:"fibroblast growth factor 1" OR TITLE:"Fibroblast growth factor 1" OR ABSTRACT:"Fibroblast growth factor 1" OR TITLE:"ECGFA" OR ABSTRACT:"ECGFA" OR TITLE:"ECGFB" OR ABSTRACT:"ECGFB" OR TITLE:"HBGF1" OR ABSTRACT:"HBGF1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FGF1, not a curated reading list.