{"entity":{"id":"fgf1","kind":"target","name":"FGF1","aka":["fibroblast growth factor 1","Fibroblast growth factor 1","ECGFA","ECGFB","HBGF1","ECGF-beta","FGF-alpha","GLIO703"],"tldr":"FGF1 (Fibroblast growth factor 1) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.","summary":"Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins.\n\nOpen Targets scores its association with cancer at 0.71 (direct and indirect evidence; datatypes literature 0.95, affected pathway 0.99, genetic association 0.04, clinical 0.65).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:3665","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3665"},{"label":"UniProt P05230","url":"https://www.uniprot.org/uniprotkb/P05230/entry"},{"label":"NCBI Gene 2246","url":"https://www.ncbi.nlm.nih.gov/gene/2246"},{"label":"Ensembl ENSG00000113578","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000113578"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.65. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"FGF1","role":["drug-target"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:3665","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3665","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P05230","url":"https://www.uniprot.org/uniprotkb/P05230/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000113578","url":"https://platform.opentargets.org/target/ENSG00000113578/associations","note":"association with cancer (MONDO_0004992) 0.71;  (GraphQL API, CC0)"}],"distribution":"one-type","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA tissue enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA FGF1: RNA tissue enriched (brain 282 nTPM); high antibody staining in 1 normal tissue. Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 1 specific cancer type at or above 0.5 (female reproductive endometrioid cancer). (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas FGF1 tissue","url":"https://www.proteinatlas.org/ENSG00000113578-FGF1/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000113578 associations","url":"https://platform.opentargets.org/target/ENSG00000113578/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:3665","ensembl":"ENSG00000113578","uniprot":"P05230","entrez":"2246","firstDescribed":1986,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Jaye et al, Science, 1986, \"Human endothelial cell growth factor: cloning, nucleotide sequence, and chromosome localization\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/3523756/","biology":"Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerisation and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signalling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signalling. Location: Secreted; Cytoplasm; Cytoplasm, cell cortex; Cytoplasm, cytosol (UniProt). Locus 5q31.3 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/fgf1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}