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FGA (Fibrinogen alpha chain) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerise to form an insoluble fibrin matrix. Fibrin has a major function in haemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilise the lesion and guide cell migration during re-epithelialisation.
Open Targets scores its association with cancer at 0.67 (direct and indirect evidence; datatypes clinical 0.43, affected pathway 0.97, literature 0.85, genetic association 0.00, animal model 0.44).
In plain words · FGA (Fibrinogen alpha chain) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
FGA (Fibrinogen alpha chain) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerise to form an insoluble fibrin matrix.
No product in this corpus aims at FGA yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA tissue enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA FGA: RNA tissue enriched (liver 17,202 nTPM); no normal tissue stained high. Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas FGA tissue; Open Targets ENSG00000171560 associations
First described 1965. Earliest sequence paper UniProt cites for the protein: Blombaeck et al, Acta Chem. Scand, 1965, "Studies on fibrinopeptides from primates". Source.
Sources: HGNC HGNC:3661 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P02671 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000171560 (association with cancer (MONDO_0004992) 0.67; (GraphQL API, CC0))
Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerise to form an insoluble fibrin matrix. Fibrin has a major function in haemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilise the lesion and guide cell migration during re-epithelialisation. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Location: Secreted (UniProt). Locus 4q31.3 (HGNC).
RNA: tissue enriched (liver 17,202 nTPM), detected in some normal tissues.
No normal tissue stained high.
RNA cancer enriched: Liver Hepatocellular Carcinoma 5,314 pTPM.
No cancer sample stained medium or high.
HPA FGA tissue · HPA FGA pathology · HPA protein class: FDA approved drug targets
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"FGA" OR ABSTRACT:"FGA" OR TITLE:"fibrinogen alpha chain" OR ABSTRACT:"fibrinogen alpha chain" OR TITLE:"Fibrinogen alpha chain" OR ABSTRACT:"Fibrinogen alpha chain") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FGA, not a curated reading list.