{"entity":{"id":"fga","kind":"target","name":"FGA","aka":["fibrinogen alpha chain","Fibrinogen alpha chain"],"tldr":"FGA (Fibrinogen alpha chain) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.","summary":"Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerise to form an insoluble fibrin matrix. Fibrin has a major function in haemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilise the lesion and guide cell migration during re-epithelialisation.\n\nOpen Targets scores its association with cancer at 0.67 (direct and indirect evidence; datatypes clinical 0.43, affected pathway 0.97, literature 0.85, genetic association 0.00, animal model 0.44).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:3661","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3661"},{"label":"UniProt P02671","url":"https://www.uniprot.org/uniprotkb/P02671/entry"},{"label":"NCBI Gene 2243","url":"https://www.ncbi.nlm.nih.gov/gene/2243"},{"label":"Ensembl ENSG00000171560","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000171560"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.43. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"FGA","role":["drug-target"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:3661","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3661","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P02671","url":"https://www.uniprot.org/uniprotkb/P02671/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000171560","url":"https://platform.opentargets.org/target/ENSG00000171560/associations","note":"association with cancer (MONDO_0004992) 0.67;  (GraphQL API, CC0)"}],"distribution":"not-established","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA tissue enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA FGA: RNA tissue enriched (liver 17,202 nTPM); no normal tissue stained high. Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas FGA tissue","url":"https://www.proteinatlas.org/ENSG00000171560-FGA/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000171560 associations","url":"https://platform.opentargets.org/target/ENSG00000171560/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:3661","ensembl":"ENSG00000171560","uniprot":"P02671","entrez":"2243","firstDescribed":1965,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Blombaeck et al, Acta Chem. Scand, 1965, \"Studies on fibrinopeptides from primates\".","firstDescribedSource":"https://www.uniprot.org/uniprotkb/P02671/entry","biology":"Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerise to form an insoluble fibrin matrix. Fibrin has a major function in haemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilise the lesion and guide cell migration during re-epithelialisation. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Location: Secreted (UniProt). Locus 4q31.3 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/fga/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}