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FANCM (Fanconi anaemia group M protein) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Breast cancer and Ovarian cancer.
DNA-dependent ATPase component of the Fanconi anaemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates.
Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes genetic literature 0.33, affected pathway 0.31, literature 0.67, genetic association 0.88, animal model 0.44).
In plain words · FANCM (Fanconi anaemia group M protein) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Breast cancer and Ovarian cancer.
FANCM (Fanconi anaemia group M protein) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Breast cancer and Ovarian cancer.
DNA-dependent ATPase component of the Fanconi anaemia (FA) core complex.
No product in this corpus aims at FANCM yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
First described 2000. Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 2000, "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". Source.
Sources: HGNC HGNC:23168 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8IYD8 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000187790 (association with cancer (MONDO_0004992) 0.62; per-cancer scores at or above 0.5: ovarian cancer 0.53, breast cancer 0.55 (GraphQL API, CC0))
DNA-dependent ATPase component of the Fanconi anaemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX. In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates. Location: Nucleus (UniProt). Locus 14q21.2 (HGNC).
Query for this target: (TITLE:"FANCM" OR ABSTRACT:"FANCM" OR TITLE:"FA complementation group M" OR ABSTRACT:"FA complementation group M" OR TITLE:"Fanconi anemia group M protein" OR ABSTRACT:"Fanconi anemia group M protein" OR TITLE:"FAAP250" OR ABSTRACT:"FAAP250" OR TITLE:"KIAA1596" OR ABSTRACT:"KIAA1596") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FANCM, not a curated reading list.