{"entity":{"id":"fancm","kind":"target","name":"FANCM","aka":["FA complementation group M","Fanconi anemia group M protein","FAAP250","KIAA1596"],"tldr":"FANCM (Fanconi anaemia group M protein) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Breast cancer and Ovarian cancer.","summary":"DNA-dependent ATPase component of the Fanconi anaemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates.\n\nOpen Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes genetic literature 0.33, affected pathway 0.31, literature 0.67, genetic association 0.88, animal model 0.44).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:23168","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:23168"},{"label":"UniProt Q8IYD8","url":"https://www.uniprot.org/uniprotkb/Q8IYD8/entry"},{"label":"NCBI Gene 57697","url":"https://www.ncbi.nlm.nih.gov/gene/57697"},{"label":"Ensembl ENSG00000187790","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000187790"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["breast-cancer","ovarian"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt keyword \"DNA repair\". Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"FANCM","role":["dna-repair"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:23168","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:23168","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q8IYD8","url":"https://www.uniprot.org/uniprotkb/Q8IYD8/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000187790","url":"https://platform.opentargets.org/target/ENSG00000187790/associations","note":"association with cancer (MONDO_0004992) 0.62; per-cancer scores at or above 0.5: ovarian cancer 0.53, breast cancer 0.55 (GraphQL API, CC0)"}],"specificitySources":[],"hgnc":"HGNC:23168","ensembl":"ENSG00000187790","uniprot":"Q8IYD8","entrez":"57697","firstDescribed":2000,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 2000, \"Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/10997877/","biology":"DNA-dependent ATPase component of the Fanconi anaemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX. In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates. Location: Nucleus (UniProt). Locus 14q21.2 (HGNC).","whereFound":["Breast cancer: Open Targets association 0.55 with breast cancer (MONDO_0007254)","Ovarian cancer: Open Targets association 0.53 with ovarian cancer (MONDO_0008170)"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/fancm/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"}]}}