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ETV5 (ETS translocation variant 5) is a gene that drives cell growth when it is altered. The public catalogues list it as a drug target, an oncogene driver and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Lung cancer, Pancreatic ductal adenocarcinoma, Neuroendocrine tumours and 4 more.
Binds to DNA sequences containing the consensus nucleotide core sequence 5'-GGAA.-3'.
CIViC holds 2 clinical evidence items and 0 assertions across 1 variant, naming Trametinib. Open Targets scores its association with cancer at 0.67 (direct and indirect evidence; datatypes literature 0.97, genetic association 0.20, somatic mutation 0.85). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Acute Myeloid Leukaemia.
In plain words · ETV5 (ETS translocation variant 5) is a gene that drives cell growth when it is altered. The public catalogues list it as a drug target, an oncogene driver and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Lung cancer, Pancreatic ductal adenocarcinoma, Neuroendocrine tumours and 4 more.
ETV5 (ETS translocation variant 5) is a gene that drives cell growth when it is altered. The public catalogues list it as a drug target, an oncogene driver and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Lung cancer, Pancreatic ductal adenocarcinoma, Neuroendocrine tumours and 4 more.
Binds to DNA sequences containing the consensus nucleotide core sequence 5'-GGAA.-3'. Location: Nucleus (UniProt).
No product in this corpus aims at ETV5 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
Tumour-specific alteration: the catalogues call it an oncogene driver (IntOGen cohort analysis finds it activated more often than chance); what a medicine would aim at or exploit is the altered form or its loss, absent from normal cells; no corpus medicine is aimed at it yet. HPA ETV5: RNA low tissue specificity; high antibody staining in 16 normal tissues; highest cancer staining testis cancer (9 of 11 high). Distribution: 7 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Lung cancer (all types), Pancreatic ductal adenocarcinoma, Neuroendocrine tumours, Skin cancer (all types), Breast cancer (all types), Colorectal cancer, Leukaemia); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 6 of scripts/fetch-target-specificity.ts.)
Sources: UniProt P41161; CIViC gene ETV5; IntOGen ETV5; Human Protein Atlas ETV5 tissue; Open Targets ENSG00000244405 associations
First described 1994. Earliest sequence paper UniProt cites for the protein: Monte et al, Oncogene, 1994, "Molecular cloning and characterization of human ERM, a new member of the Ets family closely related to mouse PEA3 and ER81 transcription factors". Source.
Sources: HGNC HGNC:3494 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P41161 (protein name, function text, keywords and locations (REST API)); CIViC gene ETV5 (2 evidence items, 0 assertions, 1 variants; diseases: Lung Cancer, Pancreatic Cancer (GraphQL API, CC0)); Open Targets ENSG00000244405 (association with cancer (MONDO_0004992) 0.67; per-cancer scores at or above 0.5: colorectal cancer 0.51, neuroendocrine neoplasm 0.56, skin cancer 0.52, breast cancer 0.52 (GraphQL API, CC0)); IntOGen ETV5 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Binds to DNA sequences containing the consensus nucleotide core sequence 5'-GGAA.-3'. Location: Nucleus (UniProt). Locus 3q27.2 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
Medium: Appendix, Breast, Bronchus, Cervix, Colon, Duodenum, Endometrium, Epididymis.
RNA cancer enhanced: Skin Cutaneous Melanoma 111 pTPM.
Medium only: carcinoid, lymphoma, renal cancer, thyroid cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"ETV5" OR ABSTRACT:"ETV5" OR TITLE:"ETS variant transcription factor 5" OR ABSTRACT:"ETS variant transcription factor 5" OR TITLE:"ETS translocation variant 5" OR ABSTRACT:"ETS translocation variant 5") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ETV5, not a curated reading list.