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ERCC1 (DNA excision repair protein ERCC-1) is a gene. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Bladder & urothelial cancer, Mesothelioma, Ovarian cancer and 1 more.
Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure.
CIViC holds 11 clinical evidence items and 0 assertions across 3 variants, naming Gemcitabine, Cisplatin, Platinum Compound and Paclitaxel and others.
In plain words · ERCC1 (DNA excision repair protein ERCC-1) is a gene. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Bladder & urothelial cancer, Mesothelioma, Ovarian cancer and 1 more.
ERCC1 (DNA excision repair protein ERCC-1) is a gene. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Bladder & urothelial cancer, Mesothelioma, Ovarian cancer and 1 more.
Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL).
No product in this corpus aims at ERCC1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA ERCC1: RNA low tissue specificity; high antibody staining in 11 normal tissues; highest cancer staining melanoma (1 of 11 high). Distribution: 4 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Bladder & urothelial cancer, Mesothelioma, Ovarian cancer, Lung cancer (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas ERCC1 tissue; Open Targets ENSG00000012061 associations
First described 1986. Earliest sequence paper UniProt cites for the protein: van Duin et al, Cell, 1986, "Molecular characterization of the human excision repair gene ERCC-1: cDNA cloning and amino acid homology with the yeast DNA repair gene RAD10". Source.
Sources: HGNC HGNC:3433 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P07992 (protein name, function text, keywords and locations (REST API)); CIViC gene ERCC1 (11 evidence items, 0 assertions, 3 variants; diseases: Lung Non-small Cell Carcinoma, Bladder Carcinoma, Malignant Pleural Mesothelioma, Epithelial Ovarian Cancer (GraphQL API, CC0))
Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4. Not functional in the nucleotide excision repair pathway. Not functional in the nucleotide excision repair pathway. Location: Nucleus; Cytoplasm (UniProt). Locus 19q13.32 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
Medium: Adipose tissue, Appendix, Bone marrow, Breast, Caudate, Cerebellum, Cerebral cortex, Endometrium.
Medium only: breast cancer, carcinoid, cervical cancer, colorectal cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"ERCC1" OR ABSTRACT:"ERCC1" OR TITLE:"ERCC excision repair 1, endonuclease non-catalytic subunit" OR ABSTRACT:"ERCC excision repair 1, endonuclease non-catalytic subunit" OR TITLE:"DNA excision repair protein ERCC-1" OR ABSTRACT:"DNA excision repair protein ERCC-1" OR TITLE:"RAD10" OR ABSTRACT:"RAD10") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ERCC1, not a curated reading list.
Shares Mesothelioma, Bladder & urothelial cancer.
Shares Mesothelioma, Ovarian cancer, Non-small-cell lung cancer.
Shares Mesothelioma, CIViC, Non-small-cell lung cancer.
Shares Mesothelioma, Non-small-cell lung cancer.
Shares Mesothelioma, CIViC, Ovarian cancer.
Shares Mesothelioma, Non-small-cell lung cancer.
Shares Mesothelioma, Non-small-cell lung cancer.
Shares Mesothelioma, Non-small-cell lung cancer.