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ERBIN (Erbin) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilise this unphosphorylated state. Inhibits NOD2-dependent NF-kappa-B signalling and pro-inflammatory cytokine secretion.
Open Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.95, affected pathway 0.97, genetic association 0.04, somatic mutation 0.23).
In plain words · ERBIN (Erbin) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
ERBIN (Erbin) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilise this unphosphorylated state.
No product in this corpus aims at ERBIN yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1999. Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 1999, "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". Source.
Sources: HGNC HGNC:15842 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96RT1 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000112851 (association with cancer (MONDO_0004992) 0.64; (GraphQL API, CC0))
Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilise this unphosphorylated state. Inhibits NOD2-dependent NF-kappa-B signalling and pro-inflammatory cytokine secretion. Acts as a mediator of keratinocyte differentiation by sequestering SHOC2 away from ERK-activating RAS complexes. Location: Cell junction, hemidesmosome; Nucleus membrane; Basolateral cell membrane; Cytoplasm (UniProt). Locus 5q12.3 (HGNC).
Query for this target: (TITLE:"ERBIN" OR ABSTRACT:"ERBIN" OR TITLE:"erbb2 interacting protein" OR ABSTRACT:"erbb2 interacting protein" OR TITLE:"Erbin" OR ABSTRACT:"Erbin" OR TITLE:"LAP2" OR ABSTRACT:"LAP2" OR TITLE:"ERBB2IP" OR ABSTRACT:"ERBB2IP") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ERBIN, not a curated reading list.