{"entity":{"id":"erbin","kind":"target","name":"ERBIN","aka":["erbb2 interacting protein","Erbin","LAP2","ERBB2IP"],"tldr":"ERBIN (Erbin) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilise this unphosphorylated state. Inhibits NOD2-dependent NF-kappa-B signalling and pro-inflammatory cytokine secretion.\n\nOpen Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.95, affected pathway 0.97, genetic association 0.04, somatic mutation 0.23).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:15842","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:15842"},{"label":"UniProt Q96RT1","url":"https://www.uniprot.org/uniprotkb/Q96RT1/entry"},{"label":"NCBI Gene 55914","url":"https://www.ncbi.nlm.nih.gov/gene/55914"},{"label":"Ensembl ENSG00000112851","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000112851"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ERBIN","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:15842","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:15842","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q96RT1","url":"https://www.uniprot.org/uniprotkb/Q96RT1/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000112851","url":"https://platform.opentargets.org/target/ENSG00000112851/associations","note":"association with cancer (MONDO_0004992) 0.64;  (GraphQL API, CC0)"}],"specificitySources":[],"hgnc":"HGNC:15842","ensembl":"ENSG00000112851","uniprot":"Q96RT1","entrez":"55914","firstDescribed":1999,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 1999, \"Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/10574462/","biology":"Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilise this unphosphorylated state. Inhibits NOD2-dependent NF-kappa-B signalling and pro-inflammatory cytokine secretion. Acts as a mediator of keratinocyte differentiation by sequestering SHOC2 away from ERK-activating RAS complexes. Location: Cell junction, hemidesmosome; Nucleus membrane; Basolateral cell membrane; Cytoplasm (UniProt). Locus 5q12.3 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/erbin/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}