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EPHA10 (Ephrin type-A receptor 10) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Thyroid cancer and Neuroendocrine tumours.
Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5.
Open Targets scores its association with cancer at 0.60 (direct and indirect evidence; datatypes literature 0.93, genetic association 0.03, clinical 0.93).
In plain words · EPHA10 (Ephrin type-A receptor 10) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Thyroid cancer and Neuroendocrine tumours.
EPHA10 (Ephrin type-A receptor 10) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Thyroid cancer and Neuroendocrine tumours.
Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5.
No product in this corpus aims at EPHA10 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA EPHA10: RNA tissue enhanced (brain 9 nTPM, intestine 13 nTPM, testis 12 nTPM); no normal tissue stained high; highest cancer staining skin cancer (5 of 12 high). Distribution: 2 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Thyroid cancer, Neuroendocrine tumours); Open Targets associates it with 1 specific cancer type at or above 0.5 (medullary thyroid gland carcinoma). (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas EPHA10 tissue; Open Targets ENSG00000183317 associations
First described 2004. Earliest sequence paper UniProt cites for the protein: Genome Res, 2004, "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Source.
Sources: HGNC HGNC:19987 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q5JZY3 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000183317 (association with cancer (MONDO_0004992) 0.60; per-cancer scores at or above 0.5: thyroid cancer 0.56, neuroendocrine neoplasm 0.54 (GraphQL API, CC0))
Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5. Location: Cell membrane; Secreted (UniProt). Locus 1p34.3 (HGNC).
RNA: tissue enhanced (brain 9 nTPM, intestine 13 nTPM, testis 12 nTPM), detected in some normal tissues.
No normal tissue stained high.
Medium only: cervical cancer, lung cancer, lymphoma, melanoma.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"EPHA10" OR ABSTRACT:"EPHA10" OR TITLE:"EPH receptor A10" OR ABSTRACT:"EPH receptor A10" OR TITLE:"Ephrin type-A receptor 10" OR ABSTRACT:"Ephrin type-A receptor 10" OR TITLE:"FLJ16103" OR ABSTRACT:"FLJ16103" OR TITLE:"FLJ33655" OR ABSTRACT:"FLJ33655") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about EPHA10, not a curated reading list.
Shares Thyroid cancer, Neuroendocrine tumours, Open Targets Platform.
Shares Thyroid cancer, Neuroendocrine tumours, Open Targets Platform.
Shares Thyroid cancer, Neuroendocrine tumours, Open Targets Platform.
Shares Thyroid cancer, Neuroendocrine tumours, Open Targets Platform.
Shares Thyroid cancer, Neuroendocrine tumours, Open Targets Platform.
Shares Thyroid cancer, Neuroendocrine tumours, Open Targets Platform.
Shares Thyroid cancer, Neuroendocrine tumours, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.