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EED (Polycomb protein EED) is a protein that switches other genes on and off. The public catalogues list it as a drug target, and the evidence so far is association rather than a proven role.
Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognises 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark.
Open Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.52, affected pathway 0.68, genetic association 0.19, somatic mutation 0.49). In OnCo, 1 product record names it (Rinzimetostat).
In plain words · EED (Polycomb protein EED) is a protein that switches other genes on and off. The public catalogues list it as a drug target, and the evidence so far is association rather than a proven role.
EED (Polycomb protein EED) is a protein that switches other genes on and off. The public catalogues list it as a drug target, and the evidence so far is association rather than a proven role.
Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene.
No product in this corpus aims at EED yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
Broadly expressed or essential: HPA finds the RNA at low tissue specificity; the 1 medicine aimed at it (Rinzimetostat) act on the wild-type protein, so normal tissue is exposed and the therapeutic window comes from the tumour's faster division or its dependence on the protein. HPA EED: RNA low tissue specificity; high antibody staining in 5 normal tissues; highest cancer staining lymphoma (1 of 11 high). Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas EED tissue; Open Targets ENSG00000074266 associations
First described 1998. Earliest sequence paper UniProt cites for the protein: Schumacher et al, Genomics, 1998, "The murine Polycomb-group gene eed and its human orthologue: functional implications of evolutionary conservation". Source.
Sources: HGNC HGNC:3188 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O75530 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000074266 (association with cancer (MONDO_0004992) 0.57; (GraphQL API, CC0))
Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognises 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A. Location: Nucleus; Chromosome (UniProt). Locus 11q14.2 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
Medium: Bronchus, Caudate, Cerebral cortex, Cervix, Colon, Duodenum, Esophagus, Gallbladder.
Medium only: breast cancer, cervical cancer, colorectal cancer, endometrial cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"EED" OR ABSTRACT:"EED" OR TITLE:"embryonic ectoderm development" OR ABSTRACT:"embryonic ectoderm development" OR TITLE:"Polycomb protein EED" OR ABSTRACT:"Polycomb protein EED" OR TITLE:"WAIT-1" OR ABSTRACT:"WAIT-1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about EED, not a curated reading list.