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Rinzimetostat is an experimental small-molecule drug from ORIC Pharmaceuticals in phase 3 trials for prostate cancer, with its target not yet stated publicly.
Rinzimetostat (ORIC-944) is a small-molecule drug developed by ORIC Pharmaceuticals. The sponsor describes its target as PRC2 (EED subunit), which OnCo does not yet have a target page for. The sponsor states: A potent and selective allosteric inhibitor of Polycomb Repressive Complex 2 (PRC2) acting via the EED subunit, intended to provide advantages over EZH2-targeted approaches. It is the investigational product in 1 recruiting or active industry-led phase 2 and phase 3 interventional cancer trial, including the phase 3 study NCT07723248 (A Study to Learn About the Investigational Drug Rinzimetostat (ORIC-944) in Patients With mCRPC Who Were Previously Treated With Abiraterone Acetate (Himalayas-1)), in prostate cancer. The largest, NCT07723248, plans to enrol 600 participants with primary completion expected 2028-03. Status reflects the highest phase registered on ClinicalTrials.gov; no efficacy results are recorded here.
A potent and selective allosteric inhibitor of Polycomb Repressive Complex 2 (PRC2) acting via the EED subunit, intended to provide advantages over EZH2-targeted approaches.
1.Rinzimetostat slips into a pocket on its target.
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Query for this drug: (TITLE:"Rinzimetostat" OR ABSTRACT:"Rinzimetostat" OR TITLE:"ORIC-944" OR ABSTRACT:"ORIC-944") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Rinzimetostat, not a curated reading list.
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Shares Prostate cancer and the tag pipeline.
Shares Prostate cancer and the tag pipeline.
Shares Prostate cancer and the tag pipeline.
Shares Prostate cancer and the tag pipeline.
Shares Prostate cancer and the tag pipeline.