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Trials
First-in-Human Study to Evaluate AZD8359 STEAP2 TCE in Participants With Prostate Cancer

trialsTrialRecruiting

First-in-Human Study to Evaluate AZD8359 STEAP2 TCE in Participants With Prostate Cancer

A phase 1/2 trial of AZD8359 in prostate cancer, run by AstraZeneca, now recruiting.

Also called: CRIUS-1

Overview Connected2

Overview

First-in-Human Study to Evaluate AZD8359 STEAP2 TCE in Participants With Prostate Cancer is a phase 1/2 interventional study registered as NCT07529717 by AstraZeneca, with 42 participants planned, started 2026-05-18 and due to reach its primary completion in 2027-11-17. Interventions recorded: AZD8359.

Setting

Phase I/II Dose Escalation & Dose Optimization Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of AZD8359, a CD8-guided T Cell-engaging Antibody That Targets STEAP2, in Adult Participants With Prostate Cancer

Phase

Phase 1/2

Sponsor

AstraZeneca

Registry

Started

2026-05-18

Enrolled

42 enrolled

Connected

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cancers

Prostate cancer

companies

Evidence strength16/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 1/2+8
42 enrolled+8
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-18 · Jude Gomila · Add 115 registry trial acronyms from the CT.gov acronym f… · diff · file

Sources & links

ClinicalTrials.gov NCT07529717

Data

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Prostate cancer

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AstraZeneca

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