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DUSP6 (Dual specificity protein phosphatase 6) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Dual specificity protein phosphatase, which mediates dephosphorylation and inactivation of MAP kinases. Has a specificity for the ERK family. Plays an important role in alleviating chronic postoperative pain.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Trametinib.
In plain words · DUSP6 (Dual specificity protein phosphatase 6) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
DUSP6 (Dual specificity protein phosphatase 6) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Dual specificity protein phosphatase, which mediates dephosphorylation and inactivation of MAP kinases. Has a specificity for the ERK family.
No product in this corpus aims at DUSP6 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA DUSP6: RNA tissue enhanced (salivary gland 213 nTPM); blood lineage group enriched (granulocytes 1,643 nTPM, monocytes 846 nTPM); no normal tissue stained high; highest cancer staining lung cancer (1 of 10 high). Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas DUSP6 tissue; Open Targets ENSG00000139318 associations
First described 1996. Earliest sequence paper UniProt cites for the protein: Groom L.A. et al, EMBO J, 1996, "Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase". Source.
Sources: HGNC HGNC:3072 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q16828 (protein name, function text, keywords and locations (REST API)); CIViC gene DUSP6 (1 evidence items, 0 assertions, 1 variants; diseases: Cancer (GraphQL API, CC0))
Dual specificity protein phosphatase, which mediates dephosphorylation and inactivation of MAP kinases. Has a specificity for the ERK family. Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia. Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain. Promotes cell differentiation by regulating MAPK1/MAPK3 activity and regulating the expression of AP1 transcription factors. Location: Cytoplasm (UniProt). Locus 12q21.33 (HGNC).
RNA: tissue enhanced (salivary gland 213 nTPM), detected in all normal tissues. Blood: group enriched (granulocytes 1,643 nTPM, monocytes 846 nTPM).
No normal tissue stained high; medium in Adrenal gland, Appendix, Bone marrow, Breast, Bronchus, Cerebral cortex and more.
RNA cancer enhanced: Thyroid Carcinoma 290 pTPM.
Medium only: carcinoid, cervical cancer, colorectal cancer, endometrial cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"DUSP6" OR ABSTRACT:"DUSP6" OR TITLE:"dual specificity phosphatase 6" OR ABSTRACT:"dual specificity phosphatase 6" OR TITLE:"Dual specificity protein phosphatase 6" OR ABSTRACT:"Dual specificity protein phosphatase 6" OR TITLE:"MKP-3" OR ABSTRACT:"MKP-3" OR TITLE:"PYST1" OR ABSTRACT:"PYST1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about DUSP6, not a curated reading list.