{"entity":{"id":"dusp6","kind":"target","name":"DUSP6","aka":["dual specificity phosphatase 6","Dual specificity protein phosphatase 6","MKP-3","PYST1"],"tldr":"DUSP6 (Dual specificity protein phosphatase 6) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.","summary":"Dual specificity protein phosphatase, which mediates dephosphorylation and inactivation of MAP kinases. Has a specificity for the ERK family. Plays an important role in alleviating chronic postoperative pain.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Trametinib.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:3072","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3072"},{"label":"UniProt Q16828","url":"https://www.uniprot.org/uniprotkb/Q16828/entry"},{"label":"NCBI Gene 1848","url":"https://www.ncbi.nlm.nih.gov/gene/1848"},{"label":"Ensembl ENSG00000139318","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000139318"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"DUSP6","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:3072","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3072","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q16828","url":"https://www.uniprot.org/uniprotkb/Q16828/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene DUSP6","url":"https://civicdb.org/features/1567","note":"1 evidence items, 0 assertions, 1 variants; diseases: Cancer (GraphQL API, CC0)"}],"distribution":"not-established","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA DUSP6: RNA tissue enhanced (salivary gland 213 nTPM); blood lineage group enriched (granulocytes 1,643 nTPM, monocytes 846 nTPM); no normal tissue stained high; highest cancer staining lung cancer (1 of 10 high). Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas DUSP6 tissue","url":"https://www.proteinatlas.org/ENSG00000139318-DUSP6/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000139318 associations","url":"https://platform.opentargets.org/target/ENSG00000139318/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:3072","ensembl":"ENSG00000139318","uniprot":"Q16828","entrez":"1848","firstDescribed":1996,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Groom L.A. et al, EMBO J, 1996, \"Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/8670865/","biology":"Dual specificity protein phosphatase, which mediates dephosphorylation and inactivation of MAP kinases. Has a specificity for the ERK family. Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia. Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain. Promotes cell differentiation by regulating MAPK1/MAPK3 activity and regulating the expression of AP1 transcription factors. Location: Cytoplasm (UniProt). Locus 12q21.33 (HGNC).","whereFound":[],"targetClass":"enzyme","prevalence":[]},"route":"/targets/dusp6/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}]}}