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DOCK8 (Dedicator of cytokinesis protein 8) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP. During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC. Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane.
Open Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.79, genetic association 0.52, genetic literature 0.76).
In plain words · DOCK8 (Dedicator of cytokinesis protein 8) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
DOCK8 (Dedicator of cytokinesis protein 8) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP.
No product in this corpus aims at DOCK8 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 2000. Earliest sequence paper UniProt cites for the protein: Ottolenghi et al, Genomics, 2000, "The region on 9p associated with 46,XY sex reversal contains several transcripts expressed in the urogenital system and a novel doublesex-related domain". Source.
Sources: HGNC HGNC:19191 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8NF50 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000107099 (association with cancer (MONDO_0004992) 0.57; (GraphQL API, CC0))
Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP. During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC. Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane. Is involved in NK cell cytotoxicity by controlling polarisation of microtubule-organising centre (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing. Location: Cytoplasm; Cell membrane; Cell projection, lamellipodium membrane (UniProt). Locus 9p24.3 (HGNC).
Query for this target: (TITLE:"DOCK8" OR ABSTRACT:"DOCK8" OR TITLE:"dedicator of cytokinesis 8" OR ABSTRACT:"dedicator of cytokinesis 8" OR TITLE:"Dedicator of cytokinesis protein 8" OR ABSTRACT:"Dedicator of cytokinesis protein 8" OR TITLE:"FLJ00026" OR ABSTRACT:"FLJ00026" OR TITLE:"FLJ00152" OR ABSTRACT:"FLJ00152" OR TITLE:"ZIR8" OR ABSTRACT:"ZIR8") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about DOCK8, not a curated reading list.