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DOCK8 (Dedicator of cytokinesis protein 8) is a gene. In the public catalogues the evidence so far is association rather than a proven role. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP. During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC. Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane. Is involved in NK cell cytotoxicity by controlling polarisation of microtubule-organising centre (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing. Location: Cytoplasm; Cell membrane; Cell projection, lamellipodium membrane (UniProt). Locus 9p24.3 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"DOCK8" OR ABSTRACT:"DOCK8" OR TITLE:"dedicator of cytokinesis 8" OR ABSTRACT:"dedicator of cytokinesis 8" OR TITLE:"Dedicator of cytokinesis protein 8" OR ABSTRACT:"Dedicator of cytokinesis protein 8" OR TITLE:"FLJ00026" OR ABSTRACT:"FLJ00026" OR TITLE:"FLJ00152" OR ABSTRACT:"FLJ00152" OR TITLE:"ZIR8" OR ABSTRACT:"ZIR8") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about DOCK8, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/dock8.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/dock8.json. Licence CC BY-NC 4.0.