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DDX43 (Probable ATP-dependent RNA helicase DDX43) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Uveal melanoma.
UniProt has no function text for Q9NXZ2; HGNC names it "DEAD-box helicase 43".
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Trametinib, Mirdametinib and Selumetinib.
In plain words · DDX43 (Probable ATP-dependent RNA helicase DDX43) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Uveal melanoma.
DDX43 (Probable ATP-dependent RNA helicase DDX43) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Uveal melanoma.
UniProt has no function text for Q9NXZ2; HGNC names it "DEAD-box helicase 43". Locus 6q13 (HGNC).
No product in this corpus aims at DDX43 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA group enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA DDX43: RNA group enriched (placenta 5 nTPM, testis 18 nTPM); high antibody staining in 1 normal tissue; highest cancer staining testis cancer (2 of 12 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Skin cancer (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas DDX43 tissue; Open Targets ENSG00000080007 associations
First described 2000. Earliest sequence paper UniProt cites for the protein: Martelange V.M.F. et al, Cancer Res, 2000, "Identification on a human sarcoma of two new genes with tumor-specific expression". Source.
Sources: HGNC HGNC:18677 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9NXZ2 (protein name, function text, keywords and locations (REST API)); CIViC gene DDX43 (1 evidence items, 0 assertions, 1 variants; diseases: Uveal Melanoma (GraphQL API, CC0))
UniProt has no function text for Q9NXZ2; HGNC names it "DEAD-box helicase 43". Locus 6q13 (HGNC).
RNA: group enriched (placenta 5 nTPM, testis 18 nTPM), detected in many normal tissues.
Medium: Lung, Placenta.
RNA cancer enriched: Testicular Germ Cell Tumor 20 pTPM.
Medium only: breast cancer, cervical cancer, liver cancer, renal cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"DDX43" OR ABSTRACT:"DDX43" OR TITLE:"DEAD-box helicase 43" OR ABSTRACT:"DEAD-box helicase 43" OR TITLE:"Probable ATP-dependent RNA helicase DDX43" OR ABSTRACT:"Probable ATP-dependent RNA helicase DDX43" OR TITLE:"DKFZp434H2114" OR ABSTRACT:"DKFZp434H2114" OR TITLE:"CT13" OR ABSTRACT:"CT13") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about DDX43, not a curated reading list.
Shares Uveal melanoma, CIViC.
Shares Uveal melanoma, CIViC.
Shares Uveal melanoma, CIViC.
Shares Uveal melanoma, CIViC.
Shares Uveal melanoma, CIViC.