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DAZAP1 (DAZ-associated protein 1) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Mantle cell lymphoma.
RNA-binding protein, which may be required during spermatogenesis.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.
In plain words · DAZAP1 (DAZ-associated protein 1) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Mantle cell lymphoma.
DAZAP1 (DAZ-associated protein 1) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Mantle cell lymphoma.
RNA-binding protein, which may be required during spermatogenesis. Location: Cytoplasm; Nucleus (UniProt).
No product in this corpus aims at DAZAP1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA DAZAP1: RNA low tissue specificity; high antibody staining in 27 normal tissues; highest cancer staining lymphoma (9 of 12 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Lymphoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas DAZAP1 tissue; Open Targets ENSG00000071626 associations
First described 2000. Earliest sequence paper UniProt cites for the protein: Tsui et al, Genomics, 2000, "Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1". Source.
Sources: HGNC HGNC:2683 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96EP5 (protein name, function text, keywords and locations (REST API)); CIViC gene DAZAP1 (1 evidence items, 0 assertions, 1 variants; diseases: Mantle Cell Lymphoma (GraphQL API, CC0))
RNA-binding protein, which may be required during spermatogenesis. Location: Cytoplasm; Nucleus (UniProt). Locus 19p13.3 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
Medium: Adipose tissue, Adrenal gland, Breast, Endometrium, Epididymis, Heart muscle, Liver, Ovary.
Medium only: carcinoid, lung cancer, thyroid cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"DAZAP1" OR ABSTRACT:"DAZAP1" OR TITLE:"DAZ associated protein 1" OR ABSTRACT:"DAZ associated protein 1" OR TITLE:"DAZ-associated protein 1" OR ABSTRACT:"DAZ-associated protein 1" OR TITLE:"MGC19907" OR ABSTRACT:"MGC19907") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about DAZAP1, not a curated reading list.