{"entity":{"id":"dazap1","kind":"target","name":"DAZAP1","aka":["DAZ associated protein 1","DAZ-associated protein 1","MGC19907"],"tldr":"DAZAP1 (DAZ-associated protein 1) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Mantle cell lymphoma.","summary":"RNA-binding protein, which may be required during spermatogenesis.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:2683","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2683"},{"label":"UniProt Q96EP5","url":"https://www.uniprot.org/uniprotkb/Q96EP5/entry"},{"label":"NCBI Gene 26528","url":"https://www.ncbi.nlm.nih.gov/gene/26528"},{"label":"Ensembl ENSG00000071626","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000071626"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["mantle-cell-lymphoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"DAZAP1","role":["biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:2683","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2683","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q96EP5","url":"https://www.uniprot.org/uniprotkb/Q96EP5/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene DAZAP1","url":"https://civicdb.org/features/10239","note":"1 evidence items, 0 assertions, 1 variants; diseases: Mantle Cell Lymphoma (GraphQL API, CC0)"}],"specificity":"broadly-expressed","distribution":"one-type","specificityNote":"Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA DAZAP1: RNA low tissue specificity; high antibody staining in 27 normal tissues; highest cancer staining lymphoma (9 of 12 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Lymphoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"Human Protein Atlas DAZAP1 tissue","url":"https://www.proteinatlas.org/ENSG00000071626-DAZAP1/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000071626 associations","url":"https://platform.opentargets.org/target/ENSG00000071626/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:2683","ensembl":"ENSG00000071626","uniprot":"Q96EP5","entrez":"26528","firstDescribed":2000,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Tsui et al, Genomics, 2000, \"Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/10857750/","biology":"RNA-binding protein, which may be required during spermatogenesis. Location: Cytoplasm; Nucleus (UniProt). Locus 19p13.3 (HGNC).","whereFound":["Mantle cell lymphoma: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/dazap1/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"mantle-cell-lymphoma","kind":"cancer","name":"Mantle cell lymphoma","route":"/cancers/mantle-cell-lymphoma/"}]}}