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DAXX (Death domain-associated protein 6) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Neuroendocrine tumours, Adrenocortical carcinoma, Pancreatic ductal adenocarcinoma and 2 more.
Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively.
Open Targets scores its association with cancer at 0.74 (direct and indirect evidence; datatypes literature 0.94, affected pathway 0.61, genetic association 0.00, somatic mutation 0.91). IntOGen calls it a driver in 3 cohorts (0 activating, 3 loss-of-function), covering Adrenocortical Carcinoma, Pancreas, Pancreatic Neuroendocrine Tumour.
In plain words · DAXX (Death domain-associated protein 6) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Neuroendocrine tumours, Adrenocortical carcinoma, Pancreatic ductal adenocarcinoma and 2 more.
DAXX (Death domain-associated protein 6) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Neuroendocrine tumours, Adrenocortical carcinoma, Pancreatic ductal adenocarcinoma and 2 more.
Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription.
No product in this corpus aims at DAXX yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 1997. Earliest sequence paper UniProt cites for the protein: Yang et al, Cell, 1997, "Daxx, a novel Fas-binding protein that activates JNK and apoptosis". Source.
Sources: HGNC HGNC:2681 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9UER7 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000204209 (association with cancer (MONDO_0004992) 0.74; per-cancer scores at or above 0.5: melanoma 0.55, neuroendocrine neoplasm 0.61, skin cancer 0.55 (GraphQL API, CC0)); IntOGen DAXX (driver in 3 cohorts (Act 0, LoF 3); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 through direct protein-protein interactions. Modulates PAX5 activity; the function seems to involve CREBBP. Location: Cytoplasm; Nucleus, nucleoplasm; Nucleus, PML body; Nucleus, nucleolus (UniProt). Locus 6p21.32 (HGNC).
Query for this target: (TITLE:"DAXX" OR ABSTRACT:"DAXX" OR TITLE:"death domain associated protein" OR ABSTRACT:"death domain associated protein" OR TITLE:"Death domain-associated protein 6" OR ABSTRACT:"Death domain-associated protein 6" OR TITLE:"DAP6" OR ABSTRACT:"DAP6") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about DAXX, not a curated reading list.
Shares Telomere maintenance & replicative immortality, Adrenocortical carcinoma, Neuroendocrine tumours, Skin cancer (all types).
Shares Adrenocortical carcinoma, IntOGen, Open Targets Platform.
Shares Adrenocortical carcinoma, Neuroendocrine tumours, Skin cancer (all types), IntOGen.
Shares Telomere maintenance & replicative immortality, Skin cancer (all types), IntOGen, Open Targets Platform.
Shares Adrenocortical carcinoma, IntOGen, Open Targets Platform.
Shares Adrenocortical carcinoma, IntOGen, Pancreatic ductal adenocarcinoma.
Shares Adrenocortical carcinoma, IntOGen, Open Targets Platform.