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CYP11B1 (Cytochrome P450 11B1, mitochondrial) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Renal cell carcinoma.
A cytochrome P450 monooxygenase mainly involved in the biosynthesis of adrenal corticoids. Catalyses a variety of reactions that are essential for many species, including detoxification, defense, and the formation of endogenous chemicals like steroid hormones. Steroid 11beta, 18- and 19-hydroxylase with preferred regioselectivity at 11beta, then 18, and lastly 19.
Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.27, animal model 0.54, genetic association 0.00, clinical 0.83).
In plain words · CYP11B1 (Cytochrome P450 11B1, mitochondrial) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Renal cell carcinoma.
CYP11B1 (Cytochrome P450 11B1, mitochondrial) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Renal cell carcinoma.
A cytochrome P450 monooxygenase mainly involved in the biosynthesis of adrenal corticoids.
No product in this corpus aims at CYP11B1 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA tissue enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA CYP11B1: RNA tissue enriched (adrenal gland 3,345 nTPM); high antibody staining in 1 normal tissue. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Renal cell carcinoma); Open Targets associates it with 1 specific cancer type at or above 0.5 (adrenal cortex carcinoma). (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas CYP11B1 tissue; Open Targets ENSG00000160882 associations
First described 1987. Earliest sequence paper UniProt cites for the protein: Chua S.C. et al, Proc. Natl. Acad. Sci. U.S.A, 1987, "Cloning of cDNA encoding steroid 11 beta-hydroxylase (P450c11)". Source.
Sources: HGNC HGNC:2591 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P15538 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000160882 (association with cancer (MONDO_0004992) 0.52; per-cancer scores at or above 0.5: renal cell carcinoma 0.52 (GraphQL API, CC0))
A cytochrome P450 monooxygenase mainly involved in the biosynthesis of adrenal corticoids. Catalyses a variety of reactions that are essential for many species, including detoxification, defense, and the formation of endogenous chemicals like steroid hormones. Steroid 11beta, 18- and 19-hydroxylase with preferred regioselectivity at 11beta, then 18, and lastly 19. Catalyses the hydroxylation of 11-deoxycortisol and 11-deoxycorticosterone (21-hydroxyprogesterone) at 11beta position, yielding cortisol or corticosterone, respectively, but cannot produce aldosterone. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate for hydroxylation and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin). Location: Mitochondrion inner membrane (UniProt). Locus 8q24.3 (HGNC).
RNA: tissue enriched (adrenal gland 3,345 nTPM), detected in some normal tissues.
No cancer sample stained medium or high.
HPA CYP11B1 tissue · HPA CYP11B1 pathology · HPA protein class: FDA approved drug targets
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"CYP11B1" OR ABSTRACT:"CYP11B1" OR TITLE:"cytochrome P450 family 11 subfamily B member 1" OR ABSTRACT:"cytochrome P450 family 11 subfamily B member 1" OR TITLE:"Cytochrome P450 11B1, mitochondrial" OR ABSTRACT:"Cytochrome P450 11B1, mitochondrial" OR TITLE:"P450C11" OR ABSTRACT:"P450C11" OR TITLE:"CPN1" OR ABSTRACT:"CPN1" OR TITLE:"CYP11B" OR ABSTRACT:"CYP11B") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CYP11B1, not a curated reading list.