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CYP11B1 (Cytochrome P450 11B1, mitochondrial) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Renal cell carcinoma. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
A cytochrome P450 monooxygenase mainly involved in the biosynthesis of adrenal corticoids. Catalyses a variety of reactions that are essential for many species, including detoxification, defense, and the formation of endogenous chemicals like steroid hormones. Steroid 11beta, 18- and 19-hydroxylase with preferred regioselectivity at 11beta, then 18, and lastly 19. Catalyses the hydroxylation of 11-deoxycortisol and 11-deoxycorticosterone (21-hydroxyprogesterone) at 11beta position, yielding cortisol or corticosterone, respectively, but cannot produce aldosterone. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate for hydroxylation and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin). Location: Mitochondrion inner membrane (UniProt). Locus 8q24.3 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"CYP11B1" OR ABSTRACT:"CYP11B1" OR TITLE:"cytochrome P450 family 11 subfamily B member 1" OR ABSTRACT:"cytochrome P450 family 11 subfamily B member 1" OR TITLE:"Cytochrome P450 11B1, mitochondrial" OR ABSTRACT:"Cytochrome P450 11B1, mitochondrial" OR TITLE:"P450C11" OR ABSTRACT:"P450C11" OR TITLE:"CPN1" OR ABSTRACT:"CPN1" OR TITLE:"CYP11B" OR ABSTRACT:"CYP11B") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CYP11B1, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/cyp11b1.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/cyp11b1.json. Licence CC BY-NC 4.0.