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CX3CL1 (Fractalkine) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-small-cell lung cancer.
Chemokine that acts as a ligand for both CX3CR1 and integrins ITGAV:ITGB3 and ITGA4:ITGB1. The CX3CR1-CX3CL1 signalling exerts distinct functions in different tissue compartments, such as immune response, inflammation, cell adhesion and chemotaxis. Regulates leukocyte adhesion and migration processes at the endothelium.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Atezolizumab.
In plain words · CX3CL1 (Fractalkine) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-small-cell lung cancer.
CX3CL1 (Fractalkine) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-small-cell lung cancer.
Chemokine that acts as a ligand for both CX3CR1 and integrins ITGAV:ITGB3 and ITGA4:ITGB1.
No product in this corpus aims at CX3CL1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA CX3CL1: RNA low tissue specificity; high antibody staining in 1 normal tissue; highest cancer staining colorectal cancer (12 of 12 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Lung cancer (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas CX3CL1 tissue; Open Targets ENSG00000006210 associations
First described 1997. Earliest sequence paper UniProt cites for the protein: Pan et al, Nature, 1997, "Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation". Source.
Sources: HGNC HGNC:10647 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P78423 (protein name, function text, keywords and locations (REST API)); CIViC gene CX3CL1 (1 evidence items, 0 assertions, 1 variants; diseases: Lung Non-small Cell Carcinoma (GraphQL API, CC0))
Chemokine that acts as a ligand for both CX3CR1 and integrins ITGAV:ITGB3 and ITGA4:ITGB1. The CX3CR1-CX3CL1 signalling exerts distinct functions in different tissue compartments, such as immune response, inflammation, cell adhesion and chemotaxis. Regulates leukocyte adhesion and migration processes at the endothelium. Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner. In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins. In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1. Location: Cell membrane; Secreted (UniProt). Locus 16q21 (HGNC).
RNA: low tissue specificity, detected in many normal tissues.
Medium: Adrenal gland, Appendix, Breast, Bronchus, Caudate, Cerebellum, Cerebral cortex, Cervix.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"CX3CL1" OR ABSTRACT:"CX3CL1" OR TITLE:"C-X3-C motif chemokine ligand 1" OR ABSTRACT:"C-X3-C motif chemokine ligand 1" OR TITLE:"Fractalkine" OR ABSTRACT:"Fractalkine" OR TITLE:"C3Xkine" OR ABSTRACT:"C3Xkine" OR TITLE:"ABCD-3" OR ABSTRACT:"ABCD-3" OR TITLE:"CXC3C" OR ABSTRACT:"CXC3C") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CX3CL1, not a curated reading list.