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CTAG2 (Cancer/testis antigen 2) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Multiple myeloma.
UniProt has no function text for O75638; HGNC names it "cancer/testis antigen 2".
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Letetresgene Autoleucel.
In plain words · CTAG2 (Cancer/testis antigen 2) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Multiple myeloma.
CTAG2 (Cancer/testis antigen 2) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Multiple myeloma.
UniProt has no function text for O75638; HGNC names it "cancer/testis antigen 2". Locus Xq28 (HGNC).
No product in this corpus aims at CTAG2 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA CTAG2: RNA tissue enhanced (heart muscle 5 nTPM, testis 10 nTPM); high antibody staining in 1 normal tissue. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Multiple myeloma); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas CTAG2 tissue; Open Targets ENSG00000126890 associations
First described 1998. Earliest sequence paper UniProt cites for the protein: Lethe B.G. et al, Int. J. Cancer, 1998, "LAGE-1, a new gene with tumor specificity". Source.
Sources: HGNC HGNC:2492 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O75638 (protein name, function text, keywords and locations (REST API)); CIViC gene CTAG2 (1 evidence items, 0 assertions, 1 variants; diseases: Multiple Myeloma (GraphQL API, CC0))
UniProt has no function text for O75638; HGNC names it "cancer/testis antigen 2". Locus Xq28 (HGNC).
RNA: tissue enhanced (heart muscle 5 nTPM, testis 10 nTPM), detected in some normal tissues.
RNA cancer enhanced: Skin Cutaneous Melanoma 25 pTPM.
No cancer stained high; medium in carcinoid, colorectal cancer, head and neck cancer, liver cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"CTAG2" OR ABSTRACT:"CTAG2" OR TITLE:"cancer/testis antigen 2" OR ABSTRACT:"cancer/testis antigen 2" OR TITLE:"Cancer/testis antigen 2" OR ABSTRACT:"Cancer/testis antigen 2" OR TITLE:"LAGE-1" OR ABSTRACT:"LAGE-1" OR TITLE:"CAMEL" OR ABSTRACT:"CAMEL" OR TITLE:"LAGE1" OR ABSTRACT:"LAGE1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CTAG2, not a curated reading list.