{"entity":{"id":"ctag2","kind":"target","name":"CTAG2","aka":["cancer/testis antigen 2","Cancer/testis antigen 2","LAGE-1","CAMEL","LAGE1","ESO2","MGC3803","MGC138724","CT6.2a","CT6.2b","LAGE-1a","LAGE-1b"],"tldr":"CTAG2 (Cancer/testis antigen 2) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Multiple myeloma.","summary":"UniProt has no function text for O75638; HGNC names it \"cancer/testis antigen 2\".\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Letetresgene Autoleucel.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:2492","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2492"},{"label":"UniProt O75638","url":"https://www.uniprot.org/uniprotkb/O75638/entry"},{"label":"NCBI Gene 30848","url":"https://www.ncbi.nlm.nih.gov/gene/30848"},{"label":"Ensembl ENSG00000126890","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000126890"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["multiple-myeloma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CTAG2","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:2492","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2492","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O75638","url":"https://www.uniprot.org/uniprotkb/O75638/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene CTAG2","url":"https://civicdb.org/features/11492","note":"1 evidence items, 0 assertions, 1 variants; diseases: Multiple Myeloma (GraphQL API, CC0)"}],"distribution":"one-type","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA CTAG2: RNA tissue enhanced (heart muscle 5 nTPM, testis 10 nTPM); high antibody staining in 1 normal tissue. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Multiple myeloma); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas CTAG2 tissue","url":"https://www.proteinatlas.org/ENSG00000126890-CTAG2/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000126890 associations","url":"https://platform.opentargets.org/target/ENSG00000126890/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:2492","ensembl":"ENSG00000126890","uniprot":"O75638","entrez":"30848","firstDescribed":1998,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Lethe B.G. et al, Int. J. Cancer, 1998, \"LAGE-1, a new gene with tumor specificity\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/9626360/","biology":"UniProt has no function text for O75638; HGNC names it \"cancer/testis antigen 2\". Locus Xq28 (HGNC).","whereFound":["Multiple myeloma: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/ctag2/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"multiple-myeloma","kind":"cancer","name":"Multiple myeloma","route":"/cancers/multiple-myeloma/"}]}}