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CSNK1E (Casein kinase I isoform epsilon) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Non-Hodgkin lymphoma and Follicular lymphoma.
Casein kinases are operationally defined by their preferential utilisation of acidic proteins such as caseins as substrates. Participates in Wnt signalling. Phosphorylates DVL1.
In plain words · CSNK1E (Casein kinase I isoform epsilon) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Non-Hodgkin lymphoma and Follicular lymphoma.
CSNK1E (Casein kinase I isoform epsilon) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Non-Hodgkin lymphoma and Follicular lymphoma.
Casein kinases are operationally defined by their preferential utilisation of acidic proteins such as caseins as substrates. Participates in Wnt signalling.
No product in this corpus aims at CSNK1E yet. Kinases are switched on by binding ATP inside the cell, so most drugs are small molecules shaped to plug that ATP pocket.
Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA CSNK1E: RNA low tissue specificity; high antibody staining in 6 normal tissues; highest cancer staining stomach cancer (1 of 9 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Lymphoma); Open Targets associates it with 1 specific cancer type at or above 0.5 (follicular lymphoma). (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas CSNK1E tissue; Open Targets ENSG00000213923 associations
First described 1995. Earliest sequence paper UniProt cites for the protein: Fish K.J. et al, J. Biol. Chem, 1995, "Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family". Source.
Sources: HGNC HGNC:2453 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P49674 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000213923 (per-cancer scores at or above 0.5: non-Hodgkin lymphoma 0.57, follicular lymphoma 0.52 (GraphQL API, CC0))
Casein kinases are operationally defined by their preferential utilisation of acidic proteins such as caseins as substrates. Participates in Wnt signalling. Phosphorylates DVL1. Phosphorylates DVL2. Phosphorylates NEDD9/HEF1. Central component of the circadian clock. Location: Cytoplasm; Nucleus (UniProt). Locus 22q13.1 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
Medium: Adrenal gland, Appendix, Bronchus, Caudate, Cerebellum, Cerebral cortex, Cervix, Endometrium.
Medium only: breast cancer, carcinoid, cervical cancer, colorectal cancer.
HPA CSNK1E tissue · HPA CSNK1E pathology · HPA protein class: FDA approved drug targets
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"CSNK1E" OR ABSTRACT:"CSNK1E" OR TITLE:"casein kinase 1 epsilon" OR ABSTRACT:"casein kinase 1 epsilon" OR TITLE:"Casein kinase I isoform epsilon" OR ABSTRACT:"Casein kinase I isoform epsilon" OR TITLE:"HCKIE" OR ABSTRACT:"HCKIE" OR TITLE:"CKIepsilon" OR ABSTRACT:"CKIepsilon") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CSNK1E, not a curated reading list.