{"entity":{"id":"csnk1e","kind":"target","name":"CSNK1E","aka":["casein kinase 1 epsilon","Casein kinase I isoform epsilon","HCKIE","CKIepsilon"],"tldr":"CSNK1E (Casein kinase I isoform epsilon) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Non-Hodgkin lymphoma and Follicular lymphoma.","summary":"Casein kinases are operationally defined by their preferential utilisation of acidic proteins such as caseins as substrates. Participates in Wnt signalling. Phosphorylates DVL1.\n\n","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:2453","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2453"},{"label":"UniProt P49674","url":"https://www.uniprot.org/uniprotkb/P49674/entry"},{"label":"NCBI Gene 1454","url":"https://www.ncbi.nlm.nih.gov/gene/1454"},{"label":"Ensembl ENSG00000213923","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000213923"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["non-hodgkin-lymphoma","follicular-lymphoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.93. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CSNK1E","role":["drug-target"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:2453","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2453","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P49674","url":"https://www.uniprot.org/uniprotkb/P49674/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000213923","url":"https://platform.opentargets.org/target/ENSG00000213923/associations","note":"per-cancer scores at or above 0.5: non-Hodgkin lymphoma 0.57, follicular lymphoma 0.52 (GraphQL API, CC0)"}],"specificity":"broadly-expressed","distribution":"one-type","specificityNote":"Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA CSNK1E: RNA low tissue specificity; high antibody staining in 6 normal tissues; highest cancer staining stomach cancer (1 of 9 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Lymphoma); Open Targets associates it with 1 specific cancer type at or above 0.5 (follicular lymphoma). (Rule 7 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"Human Protein Atlas CSNK1E tissue","url":"https://www.proteinatlas.org/ENSG00000213923-CSNK1E/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000213923 associations","url":"https://platform.opentargets.org/target/ENSG00000213923/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:2453","ensembl":"ENSG00000213923","uniprot":"P49674","entrez":"1454","firstDescribed":1995,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Fish K.J. et al, J. Biol. Chem, 1995, \"Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/7797465/","biology":"Casein kinases are operationally defined by their preferential utilisation of acidic proteins such as caseins as substrates. Participates in Wnt signalling. Phosphorylates DVL1. Phosphorylates DVL2. Phosphorylates NEDD9/HEF1. Central component of the circadian clock. Location: Cytoplasm; Nucleus (UniProt). Locus 22q13.1 (HGNC).","whereFound":["Non-Hodgkin lymphoma: Open Targets association 0.57 with non-Hodgkin lymphoma (MONDO_0018908)","Follicular lymphoma: Open Targets association 0.52 with follicular lymphoma (MONDO_0018906)"],"targetClass":"kinase","prevalence":[]},"route":"/targets/csnk1e/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"follicular-lymphoma","kind":"cancer","name":"Follicular lymphoma","route":"/cancers/follicular-lymphoma/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"}]}}