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CSMD3 (CUB and sushi domain-containing protein 3) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Hepatocellular carcinoma, Head and neck squamous cell carcinoma and 5 more.
Involved in dendrite development.
Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.42, genetic association 0.51, somatic mutation 0.76). IntOGen calls it a driver in 46 cohorts (26 activating, 19 loss-of-function), covering Bladder Urothelial Carcinoma, Invasive Breast Carcinoma, Colon Adenocarcinoma, Colorectal Adenocarcinoma, Oesophageal Adenocarcinoma, Glioblastoma Multiforme and others.
In plain words · CSMD3 (CUB and sushi domain-containing protein 3) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Hepatocellular carcinoma, Head and neck squamous cell carcinoma and 5 more.
CSMD3 (CUB and sushi domain-containing protein 3) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Hepatocellular carcinoma, Head and neck squamous cell carcinoma and 5 more.
Involved in dendrite development. Location: Cell membrane (UniProt).
No product in this corpus aims at CSMD3 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 2001. Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 2001, "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins". Source.
Sources: HGNC HGNC:19291 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q7Z407 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000164796 (association with cancer (MONDO_0004992) 0.63; (GraphQL API, CC0)); IntOGen CSMD3 (driver in 46 cohorts (Act 26, LoF 19); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Involved in dendrite development. Location: Cell membrane (UniProt). Locus 8q23.3 (HGNC).
Query for this target: (TITLE:"CSMD3" OR ABSTRACT:"CSMD3" OR TITLE:"CUB and Sushi multiple domains 3" OR ABSTRACT:"CUB and Sushi multiple domains 3" OR TITLE:"CUB and sushi domain-containing protein 3" OR ABSTRACT:"CUB and sushi domain-containing protein 3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CSMD3, not a curated reading list.