{"entity":{"id":"csmd3","kind":"target","name":"CSMD3","aka":["CUB and Sushi multiple domains 3","CUB and sushi domain-containing protein 3"],"tldr":"CSMD3 (CUB and sushi domain-containing protein 3) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Hepatocellular carcinoma, Head and neck squamous cell carcinoma and 5 more.","summary":"Involved in dendrite development.\n\nOpen Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.42, genetic association 0.51, somatic mutation 0.76). IntOGen calls it a driver in 46 cohorts (26 activating, 19 loss-of-function), covering Bladder Urothelial Carcinoma, Invasive Breast Carcinoma, Colon Adenocarcinoma, Colorectal Adenocarcinoma, Oesophageal Adenocarcinoma, Glioblastoma Multiforme and others.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:19291","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:19291"},{"label":"UniProt Q7Z407","url":"https://www.uniprot.org/uniprotkb/Q7Z407/entry"},{"label":"NCBI Gene 114788","url":"https://www.ncbi.nlm.nih.gov/gene/114788"},{"label":"Ensembl ENSG00000164796","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000164796"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["prostate","hcc","head-and-neck","gastric","breast-cancer","colorectal","esophageal","urothelial"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 26 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 19 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CSMD3","role":["oncogene-driver","tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:19291","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:19291","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q7Z407","url":"https://www.uniprot.org/uniprotkb/Q7Z407/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000164796","url":"https://platform.opentargets.org/target/ENSG00000164796/associations","note":"association with cancer (MONDO_0004992) 0.63;  (GraphQL API, CC0)"},{"label":"IntOGen CSMD3","url":"https://www.intogen.org/search?gene=CSMD3","note":"driver in 46 cohorts (Act 26, LoF 19); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"specificitySources":[],"hgnc":"HGNC:19291","ensembl":"ENSG00000164796","uniprot":"Q7Z407","entrez":"114788","firstDescribed":2001,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 2001, \"Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/11572484/","biology":"Involved in dendrite development. Location: Cell membrane (UniProt). Locus 8q23.3 (HGNC).","whereFound":["Prostate cancer: IntOGen driver in 9 cohorts (PRAD)","Hepatocellular carcinoma: IntOGen driver in 4 cohorts (HCC)","Head and neck squamous cell carcinoma: IntOGen driver in 4 cohorts (HNSC)","Gastric & gastro-oesophageal junction cancer: IntOGen driver in 4 cohorts (STAD)","Breast cancer: IntOGen driver in 3 cohorts (BRCA)","Colorectal cancer: IntOGen driver in 3 cohorts (COAD, COADREAD)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/csmd3/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"urothelial","kind":"cancer","name":"Bladder & urothelial cancer","route":"/cancers/urothelial/"},{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"},{"id":"head-and-neck","kind":"cancer","name":"Head and neck squamous cell carcinoma","route":"/cancers/head-and-neck/"},{"id":"hcc","kind":"cancer","name":"Hepatocellular carcinoma","route":"/cancers/hcc/"},{"id":"esophageal","kind":"cancer","name":"Oesophageal cancer","route":"/cancers/esophageal/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}]}}