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CRKL (Crk-like protein) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Gastric & gastro-oesophageal junction cancer and Non-small-cell lung cancer.
May mediate the transduction of intracellular signals.
CIViC holds 2 clinical evidence items and 0 assertions across 1 variant, naming Gefitinib and Dasatinib.
In plain words · CRKL (Crk-like protein) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Gastric & gastro-oesophageal junction cancer and Non-small-cell lung cancer.
CRKL (Crk-like protein) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Gastric & gastro-oesophageal junction cancer and Non-small-cell lung cancer.
May mediate the transduction of intracellular signals. Locus 22q11.21 (HGNC).
No product in this corpus aims at CRKL yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Broadly expressed or essential: HPA lists CRKL among essential proteins and finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA CRKL: RNA low tissue specificity; no normal tissue stained high; highest cancer staining ovarian cancer (3 of 12 high). Distribution: 2 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Gastric & gastro-oesophageal junction cancer, Lung cancer (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas CRKL tissue; Open Targets ENSG00000099942 associations
First described 1993. Earliest sequence paper UniProt cites for the protein: ten Hoeve et al, Oncogene, 1993, "Isolation and chromosomal localization of CRKL, a human crk-like gene". Source.
Sources: HGNC HGNC:2363 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P46109 (protein name, function text, keywords and locations (REST API)); CIViC gene CRKL (2 evidence items, 0 assertions, 1 variants; diseases: Lung Non-small Cell Carcinoma, Stomach Cancer (GraphQL API, CC0))
May mediate the transduction of intracellular signals. Locus 22q11.21 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
No normal tissue stained high.
Medium only: pancreatic cancer.
HPA CRKL tissue · HPA CRKL pathology · HPA protein class: Essential proteins
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"CRKL" OR ABSTRACT:"CRKL" OR TITLE:"CRK like proto-oncogene, adaptor protein" OR ABSTRACT:"CRK like proto-oncogene, adaptor protein" OR TITLE:"Crk-like protein" OR ABSTRACT:"Crk-like protein") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CRKL, not a curated reading list.
Shares Chronic myeloid leukaemia (KEGG map), CIViC, Non-small-cell lung cancer.