{"entity":{"id":"crkl","kind":"target","name":"CRKL","aka":["CRK like proto-oncogene, adaptor protein","Crk-like protein"],"tldr":"CRKL (Crk-like protein) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Gastric & gastro-oesophageal junction cancer and Non-small-cell lung cancer.","summary":"May mediate the transduction of intracellular signals.\n\nCIViC holds 2 clinical evidence items and 0 assertions across 1 variant, naming Gefitinib and Dasatinib.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:2363","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2363"},{"label":"UniProt P46109","url":"https://www.uniprot.org/uniprotkb/P46109/entry"},{"label":"NCBI Gene 1399","url":"https://www.ncbi.nlm.nih.gov/gene/1399"},{"label":"Ensembl ENSG00000099942","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000099942"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["gastric","nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":["cml-signalling"],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 2 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CRKL","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:2363","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2363","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P46109","url":"https://www.uniprot.org/uniprotkb/P46109/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene CRKL","url":"https://civicdb.org/features/1204","note":"2 evidence items, 0 assertions, 1 variants; diseases: Lung Non-small Cell Carcinoma, Stomach Cancer (GraphQL API, CC0)"}],"specificity":"broadly-expressed","distribution":"few-types","specificityNote":"Broadly expressed or essential: HPA lists CRKL among essential proteins and finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA CRKL: RNA low tissue specificity; no normal tissue stained high; highest cancer staining ovarian cancer (3 of 12 high). Distribution: 2 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Gastric & gastro-oesophageal junction cancer, Lung cancer (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"Human Protein Atlas CRKL tissue","url":"https://www.proteinatlas.org/ENSG00000099942-CRKL/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000099942 associations","url":"https://platform.opentargets.org/target/ENSG00000099942/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:2363","ensembl":"ENSG00000099942","uniprot":"P46109","entrez":"1399","firstDescribed":1993,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: ten Hoeve et al, Oncogene, 1993, \"Isolation and chromosomal localization of CRKL, a human crk-like gene\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/8361759/","biology":"May mediate the transduction of intracellular signals. Locus 22q11.21 (HGNC).","whereFound":["Gastric & gastro-oesophageal junction cancer: CIViC evidence names this disease","Non-small-cell lung cancer: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/crkl/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}],"pathway":[{"id":"cml-signalling","kind":"pathway","name":"Chronic myeloid leukaemia (KEGG map)","route":"/pathways/cml-signalling/"}]}}