Loading
CLIP1 (CAP-Gly domain-containing linker protein 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Lung cancer, Cervical cancer, Oesophageal cancer and 2 more.
Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking.
Open Targets scores its association with cancer at 0.66 (direct and indirect evidence; datatypes literature 0.86, affected pathway 0.93, genetic association 0.00, somatic mutation 0.45). IntOGen calls it a driver in 2 cohorts (0 activating, 2 loss-of-function), covering Cervical Squamous Cell Carcinoma, Oesophageal Squamous Cell Carcinoma.
In plain words · CLIP1 (CAP-Gly domain-containing linker protein 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Lung cancer, Cervical cancer, Oesophageal cancer and 2 more.
CLIP1 (CAP-Gly domain-containing linker protein 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Lung cancer, Cervical cancer, Oesophageal cancer and 2 more.
Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling.
No product in this corpus aims at CLIP1 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 1992. Earliest sequence paper UniProt cites for the protein: Bilbe et al, EMBO J, 1992, "Restin: a novel intermediate filament-associated protein highly expressed in the Reed-Sternberg cells of Hodgkin's disease". Source.
Sources: HGNC HGNC:10461 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P30622 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000130779 (association with cancer (MONDO_0004992) 0.66; per-cancer scores at or above 0.5: non-small cell lung carcinoma 0.59, lung cancer 0.60 (GraphQL API, CC0)); IntOGen CLIP1 (driver in 2 cohorts (Act 0, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. Location: Cytoplasm; Cytoplasm, cytoskeleton; Cytoplasmic vesicle membrane; Cell projection, ruffle (UniProt). Locus 12q24.31 (HGNC).
Query for this target: (TITLE:"CLIP1" OR ABSTRACT:"CLIP1" OR TITLE:"CAP-Gly domain containing linker protein 1" OR ABSTRACT:"CAP-Gly domain containing linker protein 1" OR TITLE:"CAP-Gly domain-containing linker protein 1" OR ABSTRACT:"CAP-Gly domain-containing linker protein 1" OR TITLE:"CYLN1" OR ABSTRACT:"CYLN1" OR TITLE:"CLIP170" OR ABSTRACT:"CLIP170" OR TITLE:"CLIP-170" OR ABSTRACT:"CLIP-170") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CLIP1, not a curated reading list.
Shares Oesophageal squamous cell carcinoma, Oesophageal cancer, IntOGen, Open Targets Platform.
Shares Oesophageal squamous cell carcinoma, Oesophageal cancer, IntOGen, Lung cancer (all types).
Shares Oesophageal squamous cell carcinoma, Oesophageal cancer, IntOGen, Open Targets Platform.
Shares Oesophageal squamous cell carcinoma, Oesophageal cancer, IntOGen.
Shares Oesophageal squamous cell carcinoma, Oesophageal cancer.
Shares Oesophageal squamous cell carcinoma, Oesophageal cancer.
Shares Oesophageal squamous cell carcinoma, Oesophageal cancer.
Shares Oesophageal squamous cell carcinoma, Oesophageal cancer.