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CLIP1 (CAP-Gly domain-containing linker protein 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Lung cancer, Cervical cancer, Oesophageal cancer and 2 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. Location: Cytoplasm; Cytoplasm, cytoskeleton; Cytoplasmic vesicle membrane; Cell projection, ruffle (UniProt). Locus 12q24.31 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"CLIP1" OR ABSTRACT:"CLIP1" OR TITLE:"CAP-Gly domain containing linker protein 1" OR ABSTRACT:"CAP-Gly domain containing linker protein 1" OR TITLE:"CAP-Gly domain-containing linker protein 1" OR ABSTRACT:"CAP-Gly domain-containing linker protein 1" OR TITLE:"CYLN1" OR ABSTRACT:"CYLN1" OR TITLE:"CLIP170" OR ABSTRACT:"CLIP170" OR TITLE:"CLIP-170" OR ABSTRACT:"CLIP-170") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CLIP1, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/clip1.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/clip1.json. Licence CC BY-NC 4.0.