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CLCN6 (H(+)/Cl(-) exchange transporter 6) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the late endosome lumen. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons.
Open Targets scores its association with cancer at 0.55 (direct and indirect evidence; datatypes literature 0.16, affected pathway 0.89, genetic association 0.05).
In plain words · CLCN6 (H(+)/Cl(-) exchange transporter 6) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
CLCN6 (H(+)/Cl(-) exchange transporter 6) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the late endosome lumen.
No product in this corpus aims at CLCN6 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1994. Earliest sequence paper UniProt cites for the protein: Nomura et al, DNA Res, 1994, "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". Source.
Sources: HGNC HGNC:2024 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P51797 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000011021 (association with cancer (MONDO_0004992) 0.55; (GraphQL API, CC0))
Voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the late endosome lumen. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters. Location: Late endosome membrane (UniProt). Locus 1p36.22 (HGNC).
Query for this target: (TITLE:"CLCN6" OR ABSTRACT:"CLCN6" OR TITLE:"Cl-/H+ antiporter 6" OR ABSTRACT:"Cl-/H+ antiporter 6" OR TITLE:"H + /Cl - exchange transporter 6" OR ABSTRACT:"H + /Cl - exchange transporter 6" OR TITLE:"CLC-6" OR ABSTRACT:"CLC-6" OR TITLE:"KIAA0046" OR ABSTRACT:"KIAA0046" OR TITLE:"ClC-6" OR ABSTRACT:"ClC-6") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CLCN6, not a curated reading list.