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CLCN6 (H(+)/Cl(-) exchange transporter 6) is a gene. In the public catalogues the evidence so far is association rather than a proven role. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the late endosome lumen. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters. Location: Late endosome membrane (UniProt). Locus 1p36.22 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"CLCN6" OR ABSTRACT:"CLCN6" OR TITLE:"Cl-/H+ antiporter 6" OR ABSTRACT:"Cl-/H+ antiporter 6" OR TITLE:"H + /Cl - exchange transporter 6" OR ABSTRACT:"H + /Cl - exchange transporter 6" OR TITLE:"CLC-6" OR ABSTRACT:"CLC-6" OR TITLE:"KIAA0046" OR ABSTRACT:"KIAA0046" OR TITLE:"ClC-6" OR ABSTRACT:"ClC-6") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CLCN6, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/clcn6.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/clcn6.json. Licence CC BY-NC 4.0.