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CD200 (OX-2 membrane glycoprotein) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues.
Open Targets scores its association with cancer at 0.50 (direct and indirect evidence; datatypes literature 0.98, genetic association 0.61, clinical 0.15).
In plain words · CD200 (OX-2 membrane glycoprotein) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
CD200 (OX-2 membrane glycoprotein) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues.
No product in this corpus aims at CD200 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Immune or microenvironment target: its medicines act on immune, stromal or bone cells rather than on the tumour cell (drug mechanisms in the corpus). HPA CD200: RNA tissue enhanced (brain 64 nTPM); blood lineage lineage enriched (B-cells 84 nTPM); high antibody staining in 10 normal tissues. Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 1 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas CD200 tissue; UniProt P41217; Open Targets ENSG00000091972 associations
First described 1987. Earliest sequence paper UniProt cites for the protein: McCaughan G.W. et al, Immunogenetics, 1987, "Characterization of the human homolog of the rat MRC OX-2 membrane glycoprotein". Source.
Sources: HGNC HGNC:7203 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P41217 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000091972 (association with cancer (MONDO_0004992) 0.50; (GraphQL API, CC0))
Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues. Location: Cell membrane (UniProt). Locus 3q13.2 (HGNC).
RNA: tissue enhanced (brain 64 nTPM), detected in many normal tissues. Blood: lineage enriched (B-cells 84 nTPM).
Medium: Adipose tissue, Adrenal gland, Appendix, Bronchus, Caudate, Cerebellum, Colon, Esophagus.
No cancer stained high; medium in breast cancer, colorectal cancer, endometrial cancer, glioma.
HPA CD200 tissue · HPA CD200 pathology · HPA protein class: CD markers
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"CD200" OR ABSTRACT:"CD200" OR TITLE:"CD200 molecule" OR ABSTRACT:"CD200 molecule" OR TITLE:"OX-2 membrane glycoprotein" OR ABSTRACT:"OX-2 membrane glycoprotein" OR TITLE:"OX-2" OR ABSTRACT:"OX-2" OR TITLE:"MOX1" OR ABSTRACT:"MOX1" OR TITLE:"MOX2" OR ABSTRACT:"MOX2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CD200, not a curated reading list.