{"entity":{"id":"cd200","kind":"target","name":"CD200","aka":["CD200 molecule","OX-2 membrane glycoprotein","OX-2","MOX1","MOX2"],"tldr":"CD200 (OX-2 membrane glycoprotein) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.","summary":"Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues.\n\nOpen Targets scores its association with cancer at 0.50 (direct and indirect evidence; datatypes literature 0.98, genetic association 0.61, clinical 0.15).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:7203","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7203"},{"label":"UniProt P41217","url":"https://www.uniprot.org/uniprotkb/P41217/entry"},{"label":"NCBI Gene 4345","url":"https://www.ncbi.nlm.nih.gov/gene/4345"},{"label":"Ensembl ENSG00000091972","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000091972"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.15. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CD200","role":["drug-target"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:7203","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7203","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P41217","url":"https://www.uniprot.org/uniprotkb/P41217/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000091972","url":"https://platform.opentargets.org/target/ENSG00000091972/associations","note":"association with cancer (MONDO_0004992) 0.50;  (GraphQL API, CC0)"}],"specificity":"immune-microenvironment","distribution":"not-established","specificityNote":"Immune or microenvironment target: its medicines act on immune, stromal or bone cells rather than on the tumour cell (drug mechanisms in the corpus). HPA CD200: RNA tissue enhanced (brain 64 nTPM); blood lineage lineage enriched (B-cells 84 nTPM); high antibody staining in 10 normal tissues. Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 1 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"Human Protein Atlas CD200 tissue","url":"https://www.proteinatlas.org/ENSG00000091972-CD200/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"UniProt P41217","url":"https://www.uniprot.org/uniprotkb/P41217/entry","note":"involvement in disease"},{"label":"Open Targets ENSG00000091972 associations","url":"https://platform.opentargets.org/target/ENSG00000091972/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:7203","ensembl":"ENSG00000091972","uniprot":"P41217","entrez":"4345","firstDescribed":1987,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: McCaughan G.W. et al, Immunogenetics, 1987, \"Characterization of the human homolog of the rat MRC OX-2 membrane glycoprotein\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/3032785/","biology":"Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues. Location: Cell membrane (UniProt). Locus 3q13.2 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/cd200/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}